Linda, A., SNYDER,Gordon, POWERS,Enrique, ZUDAIRE UBANI,Douglas, Matthew, MARVEL
申请号：
MX2018009800
公开号：
MX2018009800A
申请日:
2017.02.10
申请国别(地区):
MX
年份:
2018
代理人:
摘要：
The disclosure relates to antibodies and fragments that bind to a V-domain Ig Suppressor of T cell Activation (VISTA), and methods of eliciting certain biological responses using the antibodies. Methods of identifying anti-VISTA antibodies capable of eliciting certain biological responses are also included.The disclosure relates to antibodies and fragments that bind to a V-domain Ig Suppressor of T cell Activation (VISTA), and methods of eliciting certain biological responses using the antibodies. Methods of identifying anti-VISTA antibodies capable of eliciting certain biological responses are also included. A method of braking a vehicle having a brake member operatively connected to a wheel and an actuation system operatively connected to the brake member to apply a force thereto. The brake member is actuated when the actuation system applies force thereto. The actuation system actuates the brake member to dispose the brake member in a braking configuration in a slowing state for braking of the wheel responsive to receiving a request for slowing the vehicle. Responsive to receiving a request for immobilizing the vehicle, the brake member is actuated with the actuation system so to be disposed in the braking configuration in a parking state in which the brake member prevents rotation of the wheel. The brake member disposed in the parking state is engaged with a parking lock to thereby prevent the brake member from moving out of the parking state. Braking systems are also disclosed.La presente invención se refiere a anticuerpos y fragmentos que se unen a un supresor de Ig de dominio V de la activación de los linfocitos t (VISTA) y a procedimientos de provocar determinadas respuestas biológicas usando los anticuerpos. También se incluyen procedimientos de identificar a nticuerpos anti-VISTA capaces de provocar determinadas respuestas biológicas.
