VELLIQUETTE, RODNEY A.,维里奎提 拉德尼Ａ,維里奎提 拉德尼Ａ,RANDOLPH, RUSSELL KEITH,兰道夫 鲁塞尔Ｋ,蘭道夫 魯塞爾Ｋ,SCHOLTEN, JEFFREY D.,萧尔顿 杰佛瑞Ｄ,蕭爾頓 傑佛瑞Ｄ,RAJGOPAL, ARUN,拉吉格波 阿鲁恩,拉吉格波 阿魯恩,GELLENBECK, KEVIN,盖伦贝克 凯文,蓋倫貝克 凱文,HU, CHUN
申请号：
TW104107772
公开号：
TWI666024B
申请日:
2015.03.11
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
Compositions and methods for inhibition of triglyceride synthesis via synergistic combination of botanical extracts are described. Specifically, the present invention relates to treating or preventing weight gain or obesity, promoting weight loss, appetite suppression, or the like, as well as managing skin oil production through a synergistic inhibition of diacylglycerol acyltransferase-1 (DGAT-1) enzyme involved in the triglyceride synthesis and modulation of sterol regulatory element binding protein 1c (SREBP-1c) and/or peroxisome proliferator activated receptor gamma coactivator 1-alpha (PGC1α).本發明係描述經由植物萃取物之協同性組合來抑制三酸甘油酯合成的組成物及方法。特定地，本發明係有關於經由涉及三酸甘油酯合成之二醯基甘油醯基轉移酶-1(DGAT-1)酶的協同性抑制作用、以及固醇調節性元素結合性蛋白質1c(SREBP-1c)及/或經過氧化酶體增生劑活化之受體γ共活化劑1-α(PGC1α)的調整而治療或防止體重增加或肥胖症、促進減重、抑制食慾等、以及控制皮膚出油的方法。
