Disclosed are oral care compositions having reduced tooth staining propensity and comprising in a pharmaceutically acceptable carrier, a cationic antimicrobial agent and an anti-stain agent comprising one or more materials from each of at least two of the following chemical groups:Group 1. anionic agents,Group 2. aldehydes, ketones, and other reactive carbonyl compounds andGroup 3. nonionic ethoxylated surfactants.Examples of cationic antimicrobial agent include quaternary ammonium compounds such as cetylpyridinium chloride, cetyl pyridinium fluoride, tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride and domiphen bromide； chlorhexidine； and metal ion sources to supply metal ions such as stannous, zinc or copper.
