Phosphoribosyl pyrophosphate synthetase 2 (PRPS2) as a therapeutic target in cancer treatment

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专利权人:

发明人:

Davide Ruggero,John Thomas Cunningham

申请号：

US14760690

公开号：

US09765337B2

申请日:

2014.01.22

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The present invention provides methods of selectively killing a cell, comprising contacting the cell with an agent that inhibits phospho-ribosyl pyrophophosphate synthetase 2 (PRPS2). The present invention also provides methods of identifying a candidate agent that selectively kills neoplastic cells that are Myc-hyperactivated via inhibition of PRPS2.

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中国工程科技知识中心

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http://www.ckcest.cn/home/