PROBLEM TO BE SOLVED: To provide a guide wire having excellent operability and kink resistance.SOLUTION: The guide wire 1 includes: a wire body 10 having a welded portion 14 where a first linear wire 2 disposed on the distal end side and a second linear wire 3 disposed on the proximal end side of the first wire 2 and composed of a material with an elastic modulus higher than that of the composing material of the first wire 2 are connected by welding, the welded portion 14 being substantially smooth a cover layer arranged on the outer peripheral surface of the wire body 10 so as to cover welded portion 14 and composed of silicone resin which is a material to reduce friction of the surface around the welded portion 14 and a proximal end side cover layer arranged at the proximal end side of the cover layer and composed of fluororesin.COPYRIGHT: (C)2009,JPO&INPIT【課題】操作性および耐キンク性に優れたガイドワイヤを提供すること。【解決手段】ガイドワイヤ1は、先端側に配置された線状の第1ワイヤ2と、第1ワイヤ2の基端側に配置され、第1ワイヤ2の構成材料より弾性率が大きい材料で構成された線状の第2ワイヤ3とを、溶接により連結した溶接部14を有し、該溶接部14は実質的に平滑であるワイヤ本体10と、ワイヤ本体10の外周に、溶接部14を覆うように設けられ、溶接部14付近の表面の摩擦を低減し得る材料であるシリコーン樹脂で構成された被覆層と、前記被覆層の基端側に設けられ、フッ素樹脂で構成された基端側被覆層とを有する。【選択図】図6