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DERIVADOS DE PIRAZOLOQUINOLINAS COMO INIBIDORES DE DNA-PK
专利权人:
MERCK PATENT GMBH
发明人:
申请号:
PT11729377
公开号:
PT2588457E
申请日:
2011.06.24
申请国别(地区):
PT
年份:
2015
代理人:
摘要:
The invention relates to compounds of the formulae (I), (II) and (III), and/or physiologically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. The compounds of the formula (I) can be used for the inhibition of serine/threonine protein kinases and for the sensitisation of cancer cells to anticancer agents and/or ionising radiation. The invention also relates to the use of the compounds of the formula (I) in the prophylaxis, therapy or progress control of cancer, tumours, metastases or angiogenesis disorders, in combination with radiotherapy and/or an anticancer agent. The invention furthermore relates to a process for the preparation of the compounds of the formula (I) by reaction of compounds of the formula (II) or (III) and optionally conversion of a base or acid of the compounds of the formula (I) into one of its salts
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