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שיטות קשורות לתכשירי תא מסועף מופעל וריפויים אימונותרפיוטיים עבור מטופלים עם סרטנים מתקדמים
专利权人:
NORTHWEST BIOTHERAPEUTICS INC.
发明人:
申请号:
IL25807118
公开号:
IL258071D0
申请日:
2018.03.13
申请国别(地区):
IL
年份:
2018
代理人:
摘要:
The present disclosure provides partially mature and activated dendritic cells that produce levels of cytokines/chemokines, for example, one or any combination of and/or all of IL-6, IL-8, IL-12 and/or TNFα, that are correlated with improved clinical outcomes, significantly increased survival times and significantly increased times to tumor or cancer recurrence. The determined threshold amounts of these cytokines can be used for (i) a immunotherapeutic potency test for activated dendritic cells, (ii) selecting responder patients, (iii) rejecting non-responder patients, and (iv) to screen for dendritic cell activation or maturation agents that can also induce the production of the threshold amount of the cytokines/chemokines.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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