A method for imaging a breast of a patient with an injected contrast agent, comprising: compressing the breast； emitting and detecting a first x-ray beam at a first x-ray energy； emitting and detecting a second x-ray beam at a second, higher x-ray energy； based on the detected first and the second x-ray beam, generating a first and second type of image； identifying a region of interest on the first type and second type of image to obtain a target location for performing a biopsy on the breast of the patient, wherein the target location is generated from the identified region of interest on the first type of image and on the second type of image, wherein the first type of image is a contrast-enhanced dual energy mammography image and wherein the second type of image is dual energy 3D image.
