PROBLEM TO BE SOLVED: To produce a lung or liver metastasis animal model useful for analyzing the mechanism or cause of the metastasis of breast cancer to the lung or liver, and to provide new means for screening an inhibitory agent of the metastasis of the breast cancer to the lung and/or liver.SOLUTION: This metastasis animal model of the breast cancer to the lung and/or liver is produced by administering highly metastatic mouse breast cancer cells derived from the mouse breast cancer cell 4T1 and having an enhanced lung or liver metastatic ability to mice, and also the highly metastatic mouse breast cancer cells are used for the screening of an inhibitor of the metastasis of the breast cancer cells to the lung and/or liver.COPYRIGHT: (C)2009,JPO&INPIT【課題】乳癌の肺または肝臓転移のメカニズム、原因解明に有用な肺または肝臓転移動物モデルを作成するとともに、乳癌の肺及び/または肝臓転移抑制薬のスクリーニング手段を新たに提供する。【解決手段】マウス乳癌細胞4T1由来であって、肺、肝臓転移能が亢進した高転移性マウス乳癌細胞をマウスに投与して、乳癌の肺及び/または肝臓転移動物モデルを作成するとともに、上記高転移性マウス乳癌細胞を乳癌の肺及び/または肝臓転移抑制薬のスクリーニングに用いる。【選択図】なし
