Pieridinyl-substituted pyrrolidinone as an inhibitor of 11-β-hydroxysteroid dehydrogenase 1

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专利权人:

イーライ リリー アンド カンパニー

发明人:

オーウェン・ブレンダン・ウォレス,ヤンピン・シュ,ジェレミー・シューレンバーグ・ヨーク

申请号：

JP2009507978

公开号：

JP5225980B2

申请日:

2007.04.27

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

The present invention discloses novel compounds of Formula I: having 11&bgr；-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11&bgr；-HSD type 1 activity.

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