In one embodiment, a sensing guidewire for performing atraumatic intravascular physiologic measurements includes an elongated core wire and a sensor disposed at a distal end portion thereof. A flexure is disposed in the core wire proximal to the sensor housing. The flexure is substantially more flexible than regions of the core wire disposed on either side of the flexure, and enables a distal end portion of the guide wire to conform to and rest against a wall of vascular structure, such as an aneurism, without exerting an undue outward pressure thereon in response to making any contact with the wall.
