Disclosed is a compound of formula I with the substituent D for a manufacture of a medicament to treat intraocular pressure in human, such as ((2R,3S,4R,5R)-5-(2-chloro-6- (cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl nitrate, sodium ((2R,3S,4R,5R)-5-(6-(cyclopentylamino )-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl sulphate and ((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-(tetrahydrofuran-3-ylamino)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl nitrate.
