AJAY PUROHIT,THOMAS D. HARRIS,HEIKE S. RADEKE,SIMON P. ROBINSON,MING YU,DAVID S. CASEBIER,MICHAEL T. AZURE
申请号:
PT07869717
公开号:
PT2114873E
申请日:
2007.12.21
申请国别(地区):
PT
年份:
2013
代理人:
摘要:
Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release (thereby reducing side effects), improved quantitative data, and/or high affinity for VMAT over prior radiotracers. Methods of using the compounds to image cardiac innervation are also provided. In some instances the compounds are developed by derivatizing certain compounds with 18 F in a variety of positions: aryl, alkyl, a keto, benzylic, beta-alkylethers, gamma-propylalkylethers and beta-proplylalkylethers. Alternatively or additionally, a methyl group a is added to the amine, and/or the catechol functionality is either eliminated or masked as a way of making these compounds more stable.