Wound treatment dressings (110) comprising combinations of at least one conductive layer (114), at least one absorbent layer (116) or a moisture regulation layer (118), and methods of making and methods of use are disclosed for treatment of wounds in humans and animals: The novel dressings (110) aid in healing by helping restore the transepithelial potential of the skin, providing a functional anti-microbial barrier, and allowing for regulation of the moisture content of the wound without disturbing the wound.