您的位置: 首页 > 农业专利 > 详情页

DEVELOPMENT AND CHARACTERIZATION OF GEMCITABINE HCI COLON TARGETED LOADED POLYMERIC NANOPARTICLE TO TARGET COLORECTAL CANCER FOLLOWED BY ORAL ADMINISTRATION.
专利权人:
发明人:
MR SURJYANARAYAN MANDAL,MS BHAVISHA MAISURIYA,DR ABHAY DHARAMSI
申请号:
IN201621007287
公开号:
IN201621007287A
申请日:
2016.03.02
申请国别(地区):
IN
年份:
2017
代理人:
摘要:
ABSTRACT Title: Development and characterization of Gemcitabine Hcl colon targeted loaded polymeric nanoparticles to target colorectal cancer followed by oral administration. The present invention belongs to the fields of pharmaceutical technology, dosage form design and pharmacology. The present invention provides a novel approach of treating ulcerative colitis (such as solid cancer) through oral route by developing an optimal polymeric nanoparticle containing a solid pharmaceuticaly active principle. The GPNP was prepared by High Pressure Homogenization (HPH) method exploring the risk assessment technique. Optimized formulation with Eudragit S100 and Pluronic F-127 was formulated with sufficient control over size, size distribution, morphology and control led- release properties. Nanoparticles of the range 150 to 500 nm are obtained, non-cilio toxic and are found suitable for controlled delivery active pharmaceutical.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充