ANTI-PD-L1 ANTIBODIES AND USES THEREOF

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专利权人:

I-MAB BIOPHARMA US LIMITED

发明人:

FANG, Lei,WANG, Yongqiang,WANG, Zhengyi,GUO, Bingshi,ZANG, Jingwu

申请号：

SG11202006008W

公开号：

SG11202006008WA

申请日:

2019.03.29

申请国别(地区):

SG

年份:

2020

代理人:

摘要：

Provided are anti-PD-L1 antibodies or fragments thereof. The antibodies or fragments thereof specifically bind to the immunoglobulin C domain of the PD-L1 protein. In various example, the antibodies or fragments thereof include a VH CDR1 of SEQ ID NO: 1, a VH CDR2 of SEQ ID NO: 116, a VH CDR3 of SEQ ID NO: 117, a VL CDR1 of SEQ ID NO: 4, a VL CDR2 of SEQ ID NO: 5, and a VL CDR3 of SEQ ID NO: 6, or variants of each thereof. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and infectious diseases are also provided.

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http://www.ckcest.cn/home/