The invention provides thiazole-substituted indolin-2-ones as inhibitors of cancer stem cell pathway kinases (CSCPK) and related kinases, and methods of using these compounds, to treat subjects in need thereof.本發明提供經噻唑取代之吲哚啉-2-酮作為癌症幹細胞路徑激酶(CSCPK)及相關激酶之抑制劑,及使用此等化合物治療對其有需要之個體的方法。