Refers to a compound of formula I, wherein R1 is Halogen R2 is Oh, acyl Derivative of a natural or non natural amino acid, alcanoiloxi C1 - C4 or R1 and R2 are an epoxide R3 is C1 - C6 alkyl R4 and R5 are each together form an H or CH = CH between C13 and C14 R6 and R7 are each h, alkyl of C1 - C6 R8 Each H and R9, R10 is C1 - C6 alkyl h, Oh, c1-c4 alkoxy, halogen, R11 is H, among othersC1-c4 alkyl l is a Connector between chosen in preference to position (4 - mercapto - 4 - metilpentanoil) - piperazin - 1 - methyl phenyl [(2 - mercapto - 2 - methyl - propilamino phenyl) methyl] - 4 - [4 - ({2 - [2 - (2 - methyl - 2 - {[2 - mercapto - 2 - Methyl Propyl] amino} - ethoxy ethoxy) - ethoxy] ethyl} - methylamino) methyl] phenyl, between Others. Also referred to as a Derivative of crptoficina.A Preferred compound: (e) - (3S, 10R, 16S) - 10 - (3-chloro-4 - isobutyl metoxibencil) - 3 - [(S) - 1 - ((2R, 3R) - 3 - (4 - [4 - ({2 - [2 - (2 - (4 - methyl - 4 - metildisulfanil - pentanoilamino - ethoxy) - ethoxy) - ethoxy] ethyl} methylamino) methyl] phenyl] - oxiranyl) ethyl] - 6,6 Dimethyl 1,4 - dioxa - 8:11 - Grabarsky, ITs The Wrong Guy Ciclohexadec - 13 - eno 2,5,9,12 - tetraone. These compounds are useful in the treatment of cancerREFERIDA A UN COMPUESTO DE FORMULA I, DONDE R1 ES HALOGENO R2 ES OH, ACILO DERIVADO DE UN AMINOACIDO NATURAL O NO NATURAL, ALCANOILOXI C1-C4 o R1 Y R2 FORMAN UN EPOXIDO R3 ES ALQUILO C1-C6 R4 Y R5 SON CADA UNO H o FORMAN JUNTOS UN CH=CH ENTRE C13 Y C14 R6 Y R7 SON CADA UNO H, ALQUILO C1-C6 R8 Y R9 SON CADA UNO H, ALQUILO C1-C6 R10 ES H, OH, ALCOXI C1-C4, HALOGENO, ENTRE OTROS R11 ES H, ALQUILO C1-C4 L ES UN CONECTOR DE PREFERENCIA EN POSICION PARA ELEGIDO ENTRE (4-MERCAPTO-4-METILPENTANOIL)-PIPERAZIN-1-ILMETIL-FENIL, [(2-MERCAPTO-2-METIL-PROPILAMINO)-METIL]-FENIL, 4-[4-({2-[2-(2-{2-METIL-[2-MERCAPTO-2-METIL-PROPIL]-AMINO-ETOXI}-ETOXI)-ETOXI]-ETIL}-METILAMINO)-METIL]FENIL, ENTRE OTROS. REFERIDO ADEMAS A UN DERIVADO DE CRPTOFICINA. UN COMPUESTO PREF
