The present invention relates to a pharmaceutical composition, it is used to prevent or handle cardiac arrest and a kind of method for screening the therapeutic agent for preventing or handling cardiac arrest. The pharmaceutical composition of the disclosure includes CCN5 or CCN2 " CT protein or " CT protein is presented in theatrical prevention or treatment effect even if the cardiac arrest of the surgical intervention not with one donor heart of transplanting to a genetic carrier of the nucleotide sequence including encoding CCN5 or CCN2.
