Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.本文描述CD73抑制劑及包含該等化合物之醫藥組合物。本發明化合物及組合物適用於治療癌症、感染及神經退化性疾病。