A zebrafish seizure model, a method for establishing the same, and a method for screening anti-seizure drug using the same are disclosed. The method for establishing the zebrafish seizure model comprises the following steps: placing a zebrafish in a medium containing a induced compound represented by the following formula (I) to induce seizure-like symptom in zebrafish:wherein, the definitions of R1, R2, R3 are the same as those defined in the specification.本發明係有關於一種斑馬魚癲癇模式及其建立方法、及使用其篩選抗癲癇藥物之方法,其中斑馬魚癲癇模式之建立方法,包括下列步驟:飼養一斑馬魚於一含一誘發化合物之培養基,以誘發斑馬魚產生類癲癇症狀,其中此誘發化合物係如下式(I)所示:其中,R1、R2、R3係如說明書中所定義。
