An ultrasound deep brain stimulation method and system, the ultrasound deep brain stimulation method comprises: medically imaging a head of an animal or a human being, to generate image data； creating a head 3D digital model according to the image data； creating a 3D digital model of an ultrasound transducer array according to structure, density and acoustic parameters information of the ultrasound transducer array； generating a first ultrasound transmitting sequence according to the head 3D digital model, the 3D digital model of the ultrasound transducer array, structure, density and acoustic parameters of the skull and brain tissues, and structure, density and acoustic parameters of the ultrasound transducer array； and controlling the ultrasound transducer array to transmit ultrasound waves in accordance with the first ultrasound transmitting sequence, to implement ultrasound deep brain stimulation to the brain nucleus to be stimulated. By the use of the present invention, ultrasound can noninvasively passes through the skull to be focused in a deep brain region. By the use of different ultrasound transmitting sequences, ultrasound neuromodulation can be realized, and research on an action mechanism for the ultrasound neuromodulation can be performed.
