Zhenwei SHEN,Xiaohui CHEN,Fei XU,Yao SUN,Xiaogeng CHENG,Changlin ZHU,Chunlai JIANG,Wei KONG
申请号：
US15578124
公开号：
US20180154004A1
申请日:
2016.04.26
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides a composition for use as the protectant for a live attenuated influenza virus vaccine, comprising the following components at the following concentrations: human serum albumin: 1.0-15.0 g/L, sugar: 15.0-95.0 g/L, and sodium glutamate: 0.5-15.0 g/L. The present invention also provides a process for preparing a live attenuated influenza vaccine with the composition according to the present invention, comprising the following steps: dissolving the components of the composition according to the present invention sequentially into a pH buffer solution, adjusting the pH to a specified value, performing filtration sterilization, and adding virus stock to give the live attenuated influenza vaccine. The present invention further provides a live attenuated influenza vaccine, which may be used as an injection or nasal spray.
