PROBLEM TO BE SOLVED: To provide an antibody against fibrosis-related molecules and a medical application thereof.SOLUTION: The present invention provides an antibody that binds to CHL1 protein or an antigen-binding fragment of the antibody, wherein the antibody or its antigen-binding fragment neutralize the binding of the CHL1 protein to nonimmunologic and nonepithelial, nonhematopoietic cells of lamina propria mucosae and submucosae.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】線維化関連分子に対する抗体およびその医療応用の提供。【解決手段】CHL1タンパク質に結合する抗体又は前記抗体の抗原結合性断片であって、前記CHL1タンパク質の粘膜固有層ならびに粘膜下層の非免疫系、及び非上皮系の非血球系細胞への結合を中和する、前記抗体又は、前記抗体の抗原結合性断片。【選択図】なし
