Mayo Foundation for Medical Education and Research
发明人:
Sasantha J. Sangaralingham,John C. Burnett, Jr.,Alessandro Cataliotti,Denise M. Heublein
申请号：
US15078835
公开号：
US09857382B2
申请日:
2016.03.23
申请国别(地区):
US
年份:
2018
代理人:
摘要：
This document provides methods and materials involved in assessing renal structural alterations (e.g., renal fibrosis, glomerular basement thickening, mesangial matrix expansion, swollen podocytes, and foot processes effacement) as well as methods and materials involved in assessing outcomes. For example, methods and materials for using the level of urinary CNP (e.g., a urinary to plasma CNP ratio) to determine whether or not a mammal is developing renal structural alterations (e.g., renal fibrosis, glomerular basement thickening, mesangial matrix expansion, swollen podocytes, and foot processes effacement) as well as methods and materials for using the level of urinary CNP levels to identify patients having an increased likelihood of experiencing a poor outcome are provided.
