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COMPOSITION PHARMACEUTIQUE À LIBÉRATION CONTROLÉE AVEC RÉSISTANCE CONTRE L'INFLUENCE DE L'ÉTHANOL AU MOYEN D'UN ENROBAGE COMPORTANT DES POLYMÈRES VINYLIQUES ET EXCIPIENTS NEUTRES
专利权人:
Evonik Röhm GmbH
发明人:
申请号:
EP09779169.3
公开号:
EP2408436B1
申请日:
2009.03.18
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The invention relates to a controlled release pharmaceutical composition, comprising a core, comprising a pharmaceutical active ingredient, whereby the core is coated by an ethanol resistance conferring coating layer which has the effect of conferring the release profile of the pharmaceutical active ingredient to be resistant against the influence of ethanol, whereby the ethanol resistance conferring coating layer comprises at least 70% by weight of a mixture of a polymeric portion a) and an excipients portion b), with the polymeric portion a) is consisting of a water insoluble essentially neutral vinyl polymer or vinyl copolymer and the excipients portion b) is consisting of the excipients b1) 100 to 250% by weight of a non-porous inert lubricant, b2) 1 to 35% by weight of a cellulosic compound, b3) 0.1 to 25% by weight of an emulsifier and additionally or alternatively to b3), b4) 0.1 to 30% by weight of a plasticizer whereby the excipients of the excipients portion b) are each calculated on the dry weight of the polymer portion a).
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