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TREATING CANCER WITH CAS ENDONUCLEASE COMPLEXES
专利权人:
Stitch Bio; LLC
发明人:
Anthony P. Shuber
申请号:
US16818211
公开号:
US20200206322A1
申请日:
2020.03.13
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The invention generally relates to compositions and methods for targeted delivery of a Cas endonuclease or nucleic acid encoding a Cas endonuclease to a fusion sequence in a cancer cell but not in a healthy cell of a subject. The Cas endonuclease or nucleic acid encoding the Cas endonuclease may be complexed with a guide RNA complementary to a fusion sequence identified based on differences between a mutated sequence obtained from a cancer cell and a wild-type sequence obtained from a healthy cell of the subject. For example, the Cas endonuclease may be a Cas9 and cut DNA or a Cas13a and cut RNA. The Cas endonuclease complexes may induce cell death or cancerous cells or cause other beneficial effects.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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