Bastiaan Kruijt,Eric M. van der Snoek,Henricus J.C.M. Sterenborg,Arjen Amelink,Dominic J. Robinson,Wolfgang Neuberger
申请号：
US13357319
公开号：
US20120259187A1
申请日:
2012.01.24
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Dynamic colorectal PDT methods, devices and photosensitizer compositions to treat abnormal cell growth in anal tissue such as perianal and intra-anal intraepithelial neoplasia grade III are presented. Dynamic colorectal PDT method comprises the steps of administering topically, intravenously or orally a photosensitizer composition irradiating monitoring treatment parameters before, during and/or after irradiation. Photosensitizer composition comprises Temoporfin and excipients/carriers, appropriate for the application method. An applicator is provided for colorectal PDT treatments enhancing irradiation delivery and monitoring treatment parameters. Preferably, applicator is made of a material, used to monitor the fluence rate simultaneously while doing optical spectroscopy. Measurement probe devices are provided for monitoring PDT treatment parameters in-vivo. A device for colorectal PDT treatment is also provided, comprising laser radiation source operating at about 400 and 800 nm excitation laser radiation source operating at about 650 nm for fluorescence measurements multichannel dosimetry device long pass filter waveguides and measurement probes.
