The present invention relates to herbal extracts of Sinapis Semen, Corydalis Tuber, Pharbitidis Seed and Strychni Ignatii Semen, and a composition containing the same for treating and preventing gastrointestinal motility disorder. The extracts of the present invention have a remarkable effect of promoting gastrointestinal motility through HT3 receptor antagonism and/or HT4 receptor agonism.