WYETH LLC;JANSSEN ALZHEIMER IMMUNOTHERAPY;CRIMAGUA LIMITED;NEURALAB LIMITED;ELAN PHARMA INTERNATIONAL LIMITED;ELAN PHARMACEUTICALS INC.
发明人:
申请号：
IL21315611
公开号：
IL213156A
申请日:
2011.05.26
申请国别(地区):
IL
年份:
2014
代理人:
摘要：
The present invention is directed to methods of producing conjugates of A² peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.
