Kevin O'Connell,Subramaniam Vaidyanathan,Brad Eddy
申请号：
US16468187
公开号：
US20190381161A1
申请日:
2017.12.11
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to an oral vaccine against respiratory disease in ruminants, comprising live attenuated Mannheimia haemolytica bacteria and a Polyvinylpyrrolidone (PVP). The addition of PVP significantly improves the protective effect of vaccination on lung scores after a challenge infection. Further the PVP allows vaccination by a method of mass administration, such as by oral route via a drink. In addition the invention relates to methods for the preparation of such a vaccine, to methods for the vaccination of ruminants employing such a vaccine, and to medical uses of a composition comprising M. haemolytica bacteria.
