Models for vaccine assessment

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专利权人:

发明人:

申请号：

EP11165211.1

公开号：

EP2409714A1

申请日:

2007.06.27

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

The present invention relates to an irradiated mouse comprising a human immune model system, wherein said irradiated mouse comprises a) radiation-resistant follicular dendritic cells (FDCs) b) a population of human PBL,s and, c) antigen/antibody immune complexes, wherein said mouse is immunocompetent before irradiation. The invention also relates to methods of producing the irradiated mouse and methods which utilise the irradiated mouse.

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