BERNARD T. GOLDING,RICHARD FRANKLIN,ROBERT G.TYSON
申请号：
BRPI1015108
公开号：
BRPI1015108A2
申请日:
2010.04.01
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The present invention concerns dicarboxylic acid linked amino acid and peptide prodrugs of opioid analgesics and pharmaceutical compositions containing such prodrugs. Methods for providing pain relief, decreasing the adverse GI side effects of the opioid analgesic and increasing the bioavailability of the opioid analgesic with the aforementioned prodrugs are also provided. In one embodiment, prodrugs having the amino acid side chains of valine, leucine, isoleucine and glycine； and mono-, di- and tripeptides thereof are provided.
