Ashvinikumar V. Gavai,Weifang Shan,James Aaron Balog,Claude A. Quesnelle,Wen-Ching Han,George V. DeLucca,Daniel OMalley,Brian E. Fink
申请号：
US14429941
公开号：
US09133139B2
申请日:
2013.09.20
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed are compounds of Formula (I): wherein: R2 is phenyl, fluorophenyl, chlorophenyl, trifluorophenyl, methylisoxazolyl, or pyridinyl R3 is H, CH3, CH2(cyclopropyl), pyridinyl, chloropyridinyl, or methoxypyridinyl: and Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.
