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Nitrogen-containing heterocycle and carbocycle derivatives having TrkA inhibitory activity
专利权人:
Ltd.;Shionogi &; Co.
发明人:
Akira Yukimasa,Kazuya Kano,Kenichiroh Nakamura,Takatsugu Inoue,Motohiro Fujiu
申请号:
US16684807
公开号:
US10781210B2
申请日:
2019.11.15
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention provides a compound having TrkA inhibitory activity, or a pharmaceutically acceptable salt thereof. The present invention relates to a compound represented by Formula (I):wherein ═;X is ═;O or the like, R5 and R5A are hydrogen atoms or the like, —;A—; is —;NR1—; or the like, B is substituted or unsubstituted aromatic carbocyclyl or the like, R1 is substituted or unsubstituted alkyl or the like, R2 is a hydrogen atom or the like, —;W—; is —;CH2—; or the like, —;WA—; is —;CH2—; or the like, R13 is substituted or unsubstituted aromatic carbocyclyl or the like, R14 is substituted or unsubstituted aromatic heterocyclyl or the like, R15 is substituted or unsubstituted alkyl or the like, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same.
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