PROBLEM TO BE SOLVED: To image a fluorescence image corresponding to an interesting wavelength with high accuracy in an image pickup element with a hybrid structure.SOLUTION: An image pickup element comprises: a plurality of first pixels 109-1 to 109-m which are arranged on a first substrate 101 in a matrix and each of which has first photodiodes 103-1 to 103-m； a plurality of second pixels 110-1 to 110-m which are arranged on a second substrate 102 in a matrix and each of which has second photodiodes 104-1 to 104-m and Fabry-Perot filters 106-1 to 106-m arranged on a light receiving surface side of the second photodiode 104-1 to 104-m side； and a plurality of second microlenses 108-1 to 108-m each of which is arranged between the first substrate 101 and the corresponding one of the plurality of second photodiodes 104-1 to 104-m and has a concave shape with the light receiving surface side up.【課題】ハイブリッド構造の撮像素子において、興味の波長に対応した蛍光画像を高精度に撮像することができる。【解決手段】第１基板１０１に行列状に配置され、第１フォトダイオード１０３－１～１０３－ｍを各々有する、複数の第１画素１０９－１～１０９－ｍと、第２基板１０２に行列状に配置され、第２フォトダイオード１０４－１～１０４－ｍと、第２フォトダイオード１０４－１～１０４－ｍの受光面側に配置されたファブリーペローフィルタ１０６－１～１０６－ｍとを各々有する、複数の第２画素１１０－１～１１０－ｍと、第１基板１０１と複数の第２フォトダイオード１０４－１～１０４－ｍの対応する１つとの間に各々配置され、受光面側を上面として凹型の形状を有する、複数の第２マイクロレンズ１０８－１～１０８－ｍと、を有する。【選択図】図１
