Per Svenningsson;Lina Leinartaite;Birgitta Pettersson;Vedran Hasimbegovic;Magdalena Otrocka
发明人:
Per Svenningsson,Lina Leinartaite,Magdalena Otrocka,Vedran Hasimbegovic,Birgitta Pettersson
申请号：
US16478721
公开号：
US20190388451A1
申请日:
2018.02.06
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention relates to compounds that are useful in the treatment of parkinsonism, such as parkinsonism in connection with Parkinson's disease (PD)； dementia with Lewy bodies (DLB)； multiple system atrophy (MSA)； corticobasal degeneration (CBD)； or progressive supranuclear palsy (PSP). The said compounds include in particular idoxuridineand analogs thereof as well as their metabolic precursors, such as ropidoxuridine. The invention further relates to method for identifying compounds useful for the treatment of parkinsonism, said methods comprising detecting the capability of compound to increase the amount of GPR37 in cell membranes. The invention further relates to methods for the chemical synthesis of ropidoxuridine.
