A therapeutic procedure, Extracorporeal Autoimmune Solution Therapy (EAST), is invented for eliminating pathogenic or pathologic antibodies and immune complexes via affinity column capture, specific enzyme cleavage, and specific immune suppression/immune modulation via reinfusion of the autoantibody Fab, F(ab′)2 or Fc fragments back into the patients with a variety of acute or chronic autoimmune, inflammatory, and related other diseases.