SZETO HAZEL H.,SZETO Hazel H.,ZHAO KESHENG,ZHAO Kesheng,SCHILLER PETER W.,SCHILLER Peter W.
申请号：
SI200432120
公开号：
SI1599216T1
申请日:
2004.02.03
申请国别(地区):
SI
年份:
2014
代理人:
摘要：
The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge a minimum of four amino acids a maximum of about twenty amino acids a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1 and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.
