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MODULAR, BIOACTIVE PEPTIDES FOR BINDING NATIVE BONE AND IMPROVING BONE GRAFT OSTEOINDUCTIVITY
专利权人:
发明人:
Sheeny K.L. Levengood,Sabrina H. Brounts,William L. Murphy,Jae Sung Lee
申请号:
US13770046
公开号:
US20140235542A1
申请日:
2013.02.19
申请国别(地区):
US
年份:
2014
代理人:
摘要:
A modular peptide design strategy wherein the modular peptide has two functional units separated by a spacer portion is disclosed. More particularly, the design strategy combines a bone-binding portion and a biomolecule-derived portion. The modular peptides have improved non-covalent binding to the surface of native bone, and are capable of initiating osteogenesis, angiogenesis, and/or osteogenic differentiation.
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