The bright Ti Gong mono- Seed of this Hair inhibit Ji ?Broken cancers Fang penetrating Xing Wu Quality Ji Qi System Prepare methods. The inhibit Ji ?Broken cancers Fang penetrating Xing Wu Quality As M-SOCTA-Z, wherein mono- Fang penetrating Xing He Seed, As 188Re or 99mT of M As, Z As contain the Dan Bai Quality or victory peptide Class of the Amino acid of NH or NH2 Ji Mission. The inhibit Ji ?Broken cancers Fang penetrating Xing Wu Quality System Prepare methods, Bu Sudden include:The Will SOCTA and Dan Bai Quality or victory anti-Should of peptide utilize Zhi Class structures (- COOR) With amine Class (the raw Xi An Key of-NH ,-NH2) Key Knot Productivity (peptide bond) Key Knot, the formation SOCTA-protein Complex conjunction objects of SOCTAAnd Will The SOCTA-protein Complex close object and the anti-Should of Fang penetrating Xing He Seed M form M-SOCTA-protein or M-SOCTA-peptide, cooperation The puts the characteristic of penetrating property core Seed and the white Quality of egg, and M-SOCTA-protein or M-SOCTA-peptide with the ?Broken of what disease or can control Treatment. This Hair it is bright with Herceptin Single Zhu Kang Body Zhi ?with As, Should closed with what SOCTA Knot arrange in pairs or groups again radiate Line ?Treatment modes, control Treatment effects with increase Strong cancers (such as breast cancer).本發明提供一種抑制及診斷癌症之放射性物質及其製備方法。該抑制及診斷癌症之放射性物質為M-SOCTA-Z,其中M為一放射性核種,其為188Re或99mT,Z為含有NH或NH2基團之胺基酸之蛋白質或胜肽類。該抑制及診斷癌症之放射性物質之製備方法,其步驟包括:將SOCTA和蛋白質或胜肽反應,利用SOCTA之酯類結構(-COOR)與胺類(-NH,-NH2)鍵結產生醯胺鍵(peptide bond)之鍵結,形成SOCTA-protein複合物;及將該SOCTA-protein複合物和放射性核種M反應形成M-SOCTA-protein或M-SOCTA-peptide,配合該放射性核種及蛋白質之特性,M-SOCTA-protein或M-SOCTA-peptide可用於疾病之診斷或治療。本發明以Herceptin單株抗體之運用為例,應用於SOCTA之結合再搭配放射線的診療方式,以增強癌症(如乳癌)的治療功效。
