An apparatus for generation of a pressure pulse for treatment of soft tissue including one or more chambers having an open end operative to be sealed by skin when applied thereto rendering the chamber air tight, a vacuum pump communicating with the chamber and operative to generate at least partial vacuum inside the chamber and a plunger operative to move axially relative to the chamber towards and away from the skin and engage the skin without breaking the air tightness of the chamber and wherein the plunger is operative to engage skin against vacuum forces during a first phase and disengage the skin during a second phase.