It discloses and is related to or from anti-JAG1 antibody composition and method. Fully human antibodies are disclosed, bind JAG1, JAG1- the binding fragment and derived product of such antibody, the JAG1- binding polypeptides including such fragment are more specifically. Further still, disclose antibody, antibody fragments and derived product and polypeptide, the unit including such polynucleotides, antibody as production method, antibody fragments and derived product and polypeptide as the nucleic acid of coding polypeptide, and method, it uses such antibody, antibody fragments and derived product and polypeptide, and method or diagnosis including processing have the main body of JAG1 related disorders or situation. It also discloses a kind of for handling JAG1- expression lumps, including hepatocellular carcinoma and carcinoma squamosum, with the method for tumor disease, it is selected from group, by rheumatoid arthritis, experimental lung damage, atherosis, is made up of chronic liver disease caused by hepatitis C virus, ischemic myocardial injury and cardiac arrest.
