ANTIBODY OR FRAGMENT THEREOF THAT BINDS TO PDGFR-ALPHA, NUCLEIC ACID ENCODING THE SAME, VECTORS, HOST CELLS AND CONJUGATES COMPRISING SUCH ANTIBODY AND USES OF SUCH ANTIBODY IN THE MANUFACTURE OF MEDICAMENTS
BLAKEY, DAVID, CHARLES,GAZIT-BORNSTEIN GADI,YANG, XIADONG,CARTLIDGE, SUSAN ANN,LAING, NAOMI,KANG, JASPAL, SINGH,FOLTZ, IAN,TAYLOR, LAURA
申请号：
IL222833
公开号：
IL222833A
申请日:
2012.11.01
申请国别(地区):
IL
年份:
2012
代理人:
摘要：
Targeted binding agents directed to the antigen PDGFR-alpha and uses of such agents are disclosed herein. More specifically the invention relates to fully human monoclonal antibodies directed to the antigen PDGFR-alpha and uses of these antibodies. Aspects of the invention also relate to hybridomas or other cell lines expressing such antibodies. The described targeted binding agents and antibodies are useful as diagnostics and for the treatment of diseases associated with the activity and/or overexpression of PDGFR-alpha.Linvention concerne des agents liants ciblés dirigés contre lantigène PDGFR-alpha, ainsi que les utilisations de ces agents. Linvention concerne plus particulièrement des anticorps monoclonaux entièrement humains dirigés contre lantigène PDGFR-alpha, ainsi que les utilisations de ces anticorps. Des aspects de linvention concernent également des hybridomes ou autres lignées cellulaires exprimant ces anticorps. Les agents liants ciblés et les anticorps selon linvention sont utiles dans le diagnostic et le traitement de maladies associées à lactivité et/ou à la surexpression de PDGFR-alpha.
