University of Miyazaki;Fujita Health University;Perseus Proteomics Inc.
发明人:
申请号：
EP14842086.2
公开号：
EP3042956A4
申请日:
2014.09.05
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
It is an object of the present invention to provide an anti-ITGA6/B4 human antibody, which specifically recognizes ITGA6B4 complex expressed on a cell membrane and inhibits the adhesion of the ITGA6B4 complex to laminin, so as to inhibit adhesion of cancer cells to a bone marrow niche, and which is also capable of remarkably enhancing the effects of an anticancer agent on an anticancer agent resistant strain. The present invention provides an antibody against integrin A6B4, wherein the antibody specifically recognizes a human integrin A6B4 complex and inhibits intercellular adhesion.
