VENKATARAMANI, CHANDRASEKAR,HUANG, WOLIN,MEHROTRA, MUKUND,SONG, YONGHONG,XU, QING,BAUER, SHAWN M.,PANDEY, ANJALI,KANE, BRIAN,JIA, ZHAOZHONG J.,ROSE, JACK W.
申请号：
CA2728893
公开号：
CA2728893C
申请日:
2009.04.16
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention is directed to compounds of formula I-V and tautomersthereof or pharmaceuticallyacceptable salts, esters, and prodrugs thereof which are inhibitors of sykkinase. The present invention is also directed to intermediatesused in making such compounds, the preparation of such a compound,pharmaceutical compositions containing such a compound,methods of inhibition syk kinase activity, methods ofinhibilion the plateletaggregation, and methods to prevent or treat a numberof conditions mediated at least in part by syk kinase activity, such ascardiovascular disease, inflammatory disease andautoimune disease and cell proliferative disorder. Formula (I) Y1 is selectedfrom the group consisting of: (a) and (b)； Z is O or S； D1 isselected from the group consisting of: (a) phenyl substituted with a group, R5(b) naphthyl (c) C3-8cycloalkyl (d) heteroaryl (e)heterocyclyl
