OCUNEXUS THERAPEUTICS, INC.;UNIVERSITY OF AUCKLAND
发明人:
GREEN, COLIN,KIM, YERI,DUFT, BRADFORD
申请号：
CA3022763
公开号：
CA3022763A1
申请日:
2017.05.02
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Compounds and compositions comprising a gap junction channel or hemichannel blocker or inhibitor, and methods of use thereof, are provided for the treatment or prevention of vascular and other diseases, disorders, and conditions. Specifically, the disclosure provides peptides and peptide mimetics having pharmacokinetic and pharmacodynamic properties useful for modulating gap junction communication and hemichannel opening and other activities, wherein the peptides and peptide mimetics described herein are gap junction channel inhibitors. Further disclosed are sequences of the peptides and peptide mimetics.
