3,3-DIFLUOROPIPERIDINE CARBAMATE HETEROCYCLIC COMPOUNDS AS NR2B NMDA RECEPTOR ANTAGONISTS

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专利权人:

Gideon Shapiro;Rugen Holdings (Cayman) Limited

发明人:

Gideon Shapiro

申请号：

US16810258

公开号：

US20200299300A1

申请日:

2020.03.05

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Disclosed are chemical entities of Formula (I), wherein R1 and Z are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of Formula (I), and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of Formula (I).

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