JILL NUNEZ,STEFAN PEUKERT,GUO HE,MICHAEL A. DECHANTSREITER,CLAYTON SPRINGER,HEATHER ELIZABETH BURKS,YINGCHUAN SUN,NOEL MARIE THOMSEN,GEORG SCOTT FRANCE - TRIA,BING YU
申请号：
ARP140100517
公开号：
AR094704A1
申请日:
2014.02.19
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Claim 1: a compound of the formula (1), in which n is selected from 0, 1 and 2； M is selected from 0,1 and 2； X is selected from or and nr u2076； where r u2076 c u2081 u208b u2084 is alkyl； y u00b9 is selected from N and cr u2077； where r u2077 is selected from Hydrogen, alkyl and r u00b9 c u2081 u208b u2084； Hydrogen； R u00b2 is selected from Hydrogen and Halo； r u00b3 is selected from Ch u2082ch u2082r u2078 u1d47 and cr u2078 u1d43 = cr u2078 u1d43r u2078 u1d47； where each r u2078 u1d43 independently selected from Hydrogen,And c u2081 u208b u2084 Fluorine alkyl； and r u2078 u1d47 is selected from or u2079 u1d43, - C (o) - C (o) nr u2079 u1d43r u2079 u1d47, - C (o) nhor u2079 u1d43, - C (o) x u00b2r u2079 u1d43 heteroaryl and a 5 - 6 members selected from the group of formulas (2) where the dotted line indicates the - ch u2082ch u2082 or fixing Point with CR u2078 u1d43 = cr u2078 u1d43 of r u00b3； where X is alquileno c u2081 u208b u2084； r u2079 u1d43 and r u2079 u1d47 independently selected from Hydrogen, alkyl c u2081 u208b u2084,C u2081 u208b u2084 hydroxyl substituted alkyl, alkyl substituted c u2081 u208b u2084 Halo - and - x u2074r u00b9 u2070； where x u2074 is selected from a Link and alquileno c u2081 u208b u2083； and r u00b9 u2070 is a saturated Ring of 4 - 6 members that contains 1 to 3 Atoms independently selected from o, N and S； Where the r u2078 u1d47 of heteroaryl,It is replaced or not replaced by 1 to 3 groups independently selected from alkyl and cycloalkyl c u2081 u208b u2084 c u2083 u208b u2088； r u2074 is selected from Hydrogen, alkyl c u2081 u208b u2084,Halo and c u2081 u208b u2083 alkoxyl； r u2075 is selected from aryl and heteroaryl c u2086 u208b u2081 u2080 5 - 6 members selected from the group of Formulae (3) where the dotted line indicates the point of fixation with the core of benzothiophene； wherein Said aryl or heteroaryl c u2086 u208b u2081 u2080 Or r u2075 is replaced by 1 to 3 groups selected from r u2075 u1d43 - X - and r u2075
