Disclosed herein are 5 or 8-substituted imidazo[1,5-a]pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo[1,5-a]pyridines, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain 5 or 8-substituted imidazo[1,5-a]pyridines that can be useful for inhibiting indoleamine 2,3-dioxygenase and/or tryptophane 2,3-dioxygenase and for treating diseases or disorders mediated thereby.本申請公開了5或8-取代之咪唑並[1,5-a]吡啶和包含至少一種上述5或8-取代之咪唑並[1,5-a]吡啶之醫藥組合物、它們之製備方法，以及它們在療法中之用途。本申請公開了某些5或8-取代之咪唑並[1,5-a]吡啶，其可用於抑制吲哚胺2,3-二加氧酶和/或色氨酸2,3-二加氧酶且用於治療吲哚胺2,3-二加氧酶和/或色氨酸2,3-二加氧酶介導之疾病或病症。
